I wanted to collect a few more of my thoughts after reading The Cutie Map discussion thread.
My favorite antagonists of the show are these normal ponies, like Trixie and Sunset Shimmer. It remains to be seen whether Starlight Glimmer will be well developed, though. I have no complaints about her yet, but I hope her personal history gets attention (and makes sense) when we see her again.
Continuity with the movies could be improved. Rainbow Rocks shows the Mane Six already at work