The show made me appreciate, who I am far more.
My biggest bane was always my self esteem, or, to be more specific - a complete lack of it. As a rather soft spoken and "in the clouds" kind of person I had to deal with criticism on a regular basis with people expecting me to "be a man" aka - tough, stone cold, with very specific set of hobbies (what's up with that, I don't like watching sports and suddenly people look at me like some sort of alien xD). Any "deviation" from that rather narrow minded point of view was sin as a weakness.
Needless to say, having the same thing, however ridiculous it may be literally pounded into Your brain with some sort of mental sledgehammer makes You eventually believe that. Since I couldn't just change to "fit in" (nor did I ever want to as such attempts made me only feel worse) my self esteem plummeted rather quickly with me seeing myself as a naive, paper man with nothing to present to the wide world. I will tell You all this - it wasn't fun. Today I laugh at that (and feel happy I never gave in) but back then it took away much of my enjoyment from pretty much anything.
Then there's this show, where I'm suddenly told that no matter who I am - I am worthwhile. Even more, there are actual fans behind it and in large numbers too, who tell me the same thing - I'm worthwhile. There's a character who faces my very own struggles and remains true to herself and through that becomes strong. Only that strength is hidden as there's more behind the word than some brute force or ability to tell someone to "get lost". That was a life changer to me. That hasn't fixed all my problems, obviously, it takes even more than that for this to happen, but set me on a right path.
I am certain that if I never ran into this show then today I'd be another "boring" human, who killed their passions and lives only to work, eat and sleep. I am certain, because this is exactly the kind of ideal that I was being pummelled with.
It's no exaggeration to say that I owe this show my life today. I wouldn't be myself if it wasn't for ponies. And I am proud of it.