Well, im not too good at the whole 'would X change' kinda things, but i think it would. I dont guess it would impact it as 'Japan wins', but the war would have been longer.
Now, if you mean every US ship bound for Leyte was destroyed? The war goes on, perhaps Japan takes some land back or even manages to rebuild some of its navy. But the US was just too powerful and could produce ships so fast i dont think the outcome would have changed. They wouldve built those ships right back and gone in.