Yes, a lot of anime has made me cry.
Anyone who's seen SAO will know what I mean when I say Red Nosed Reindeer ;_;
Also, the ending of Death Note ;_;
And literally every character death in Attack on Titan ;_;
Personally, I think that Spike doesn't really have as good a personality as all the other characters. He seems to just be a stereotypical lackey for Twilight to me :/
I've never really thought about it. I'm a guy and have never really had any issues with that. I wouldn't say I'm happy but I'm certainly not unhappy. I don't really mind the way I was born personally