Adblock exists for this reason, silly.
YouTube's homepage layout is okay. It's very simplistic, yet it remains easy to navigate. Now, the 2012 channel layout is what irritates me. It's atrocious.
Prior to the update, channels were heaps easy to navigate. The previous design managed to bundle everything into a one place, and kept things easy to access quickly. Videos could be viewed using the sidebar, with the above panel to choose which of the user's playlist to select a video from. Profile info was easy to see and organize, with any section you wanted to add, be it other channels, or friends/comments/etc., all at your fingertips and without switching any pages. Also, channel customization was tremendously simple, anyone could paint their channels with any colours they pleased. Heck, the traditional GUI style didn't even need to be used, someone could design an alternate style and upload it as a background image. It was stylish overall.
The current channel design is a giant Easter egg hunt. Have a lot of videos, or visiting a user that does? 1,000 sorrows, if you can't remember the name of the particular video you seek, you're going to have to switch to a different page and dig through pages of giant thumbnails until you find the correct one. You know what? That's pretty much the eternity of the new layout, pages and giant thumbnails, sometimes unnecessarily encapsulated in white blocks. Anyone can post comments, sure, but now the area used to do so hangs out in the right sidebar, and the only way to view any comment is by flipping to a separate channel page. Oh, how could I forget, the current "customization" selections. Users are forced to choose one of four possible layout options, despite each one looking nearly identical to the rest in every aspect. Words are insignificant in describing my animosity towards this disgrace towards expression. The colour scheme is unchangeable, and any person using this redesign is forced to face a dull collection of black and grey gradients. Honestly, YouTube is trying to lock everything into this box that limits expression, and we have no choice but to conform to their unreasonable layout decisions.
...but, you could, um, you know, s-send YouTube some feedback. I'm sure they w-would appreciate it...