If I'm to interpret this as about my *gender* the biggest things would be that my body doesn't match it and social stigma/phobia. Plus the general sexism women face, trans issues aside. That and impractical clothes. Who decided women don't need pockets...
If it's about my sex, then it doesn't match with my identity, my deep voice, and general body structure. I grow a beard I don't want, but not even a full one. I'm impractically tall, to the point where clothes are hard to find, fitting in cars is difficult, etc. I'll never be able to have kids, which I admittedly don't think I want anyways, but having the option would have been nice.