Anxiety is the main thing for me, lots of social anxiety, also just general. It really sucks and it can really put a damper on doing things in life. Have had it for as long as I can remember.
It would have to be between Yoshi's Island and Super Mario 64, Both have good memories tied to them and I'm glad they were part of growing up for me. If I had to choose one then it would be Yoshi's Island.