Setra Kassbohrer is a German manufacturer of Transit Buses and Highway Coaches. It is a wholly owned by Daimler-Mercedes Benz and represents the majority of Mercedes Benz Diesel business interests in regions where it would be difficult to get market share alone.

Setra began building buses in 1958 with its first model the Type S, Since then all Setra models carry this designation. Setra is an abbreviation for the German word "selbsttragend" which means "Self Supporting". This refers to the construction of Setra buses which are unibody integral instead of the "Body on frame" designs which were very common.

Setra's presence in North America has largely been dictated by parent company and primary shareholder Daimler AG-Mercedes-Benz. In 2012 Mercedes-Benz Diesel acquired large controlling interests in Motor Coach Industries (MCI) saving MCI from bankruptcy. Setra buses are sold through MCI's large distribution network in the North American market.

Setra has struggled to gain market share in North America due to the highly established domestic market for highway coaches sold in its caliber. Setra buses cost twice as much as MCI or Prevost models in similar specifications. Setra often relies on upselling its "German Engineering" to justify the high cost of acquisition and maintenance

Setra's closest competition comes from Van Hool of Belgium. Van Hool also builds and sells European style coaches and buses in North America but isn't reliant upon one distribution source. Van Hool also builds Double Deckers which are becoming popular in North America.