Harry Potter has several tear-jerking moments both in the films and books. One of them that stands out to me is the moment Harry says goodbye to Ron and Hermione.

What really makes it stand out is the sorrow throughout. Harry just found out that he's a horcrux, and the only way Voldemort could die is he kills him, destroying the horcrux with it. The ragged breathing indicates he's still coping with not only the fact that he has to die, but leave his closest friends behind. Hermione and Ron suspected it too, Harry guessed, but Hermione's reaction's just devastating.

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Hermione: *sobs* I'll go with you.

After everything they all went through, Hermione wanted to be beside Harry, both for support and to keep him alive. Additionally, she (and Ron, who cried silently) realized that their friendship was about to end. Before they become adults, it's over. It's "goodbye." And it hurts horribly. After watching so many friends and relatives die in the Battle, this hurt the most. Combine that with the bleak gray set design, it's one of the best moments of the entire series.