Applejack: wrestle with her affectionately and say "Oh AJ, ya' big dope, when did you get so clumsy?" And we would continue to muck about together, giggling and giving each other noogies.
Big Macintosh: I would be dead. Not that I hold it against him or anything, but he is fricken' huge. XD
Derpy: cuddle and kiss her between her lovely derped eyes.
Screwball: steal her and lock her in my apartment so I can take care of her. After all, she has nopony to look after her now. Her daddy Discord seems to have forgotten her. :'(