This will never happen. It is highly, highly proabable that it would never happen,but if one of the Mane 6 were to be removed form the show, through whatever means that may be, who would you miss the most? Whoose absence would have the boggest impact on the mane six and how would it affect them?
For me I think Rainbow Dash, she isn't even my favourite pony but I do feel the show would be kind of...empty... Without her. It would also impact the mane six quite alot, not just due to the loss of a friens but the weather would be left unwatched and uncontroable.
This will proably never happen thank goodness, but whose absence would you miss the most from the mane six? How would they affect the plot and the other reamining members of the mane six?