Okay, so some people have pointed out that not much has changed about the characters themselves. However, analyzing season 5, there hasn't been much of your typical friendship lessons focusing on the Mane Six. Every episode so far has either been about their status, focused only on the Mane Six themselves without outside interaction, focused on characters other than the Mane Six or focused on a topic other than friendship.
I'm going to skip "The Cutie Map" as it's only natural that a two-parter would focus on such a major event, so I'll start with Castle Sweet Castle:
Castle Sweet Castle - The focus was mainly on the Mane Six themselves and not on the interaction with the outside world.
Bloom and Gloom - The focus was on the Cutie Mark Crusaders, mainly Apple Bloom.
Tanks for the Memories - The focus was on hibernation, which wasn't related to friendship. Rainbow Dash wasn't shown interacting with other ponies, even though she usually would be during season changes.
Appleoosa's Most Wanted - The focus was on the Cutie Mark Crusaders. The way Applejack was treated by other ponies wasn't much different, but it wasn't major enough to subvert the idea that her status has changed the way she's perceived either. Her main experiences in the episode weren't related to friendship or any kind of non-family-related social interaction.
Make New Friends But Keep Discord - The main focus was on Discord, Fluttershy was more or less just a plot point in this episode, and even if you don't see it that way, it still does nothing to subvert what I'm talking about. Also worth noting is how being invited to the Grand Galloping Gala was treated as "normal" for them rather than a big deal. I guess you could justify it considering they've been before, and the gala is known to be terrible.
The Lost Treasure of Griffonstone - We finally get a "friendship" lesson that focuses on the Mane Six (well, Pinkie Pie and Rainbow Dash) but the focus is on their role as spreaders of friendship, rather than experiencing the problems first hand.
Slice of Life - N/A
Princess Spike - The focus was on Spike, and actually emphasized how Twilight is treated for her status. Not as bad as all of the characters being over glorified, I guess...
Party Pooped - The focus was on the relationships between two lands, rather than your typical, everyday friendship lesson. Pinkie wasn't explicitly treated differently for her status, but it doesn't subvert the idea either.
Amending Fences - This episode features a typical friendship lesson that focuses on Twilight, but the fact that she's a princess is considered a big deal.
Do Princesses Dream of Magic Sheep - Focuses on a disaster that's not so much related to friendship.
As you can see, so far we haven't had any episodes in season 5 focusing on the Mane Six that are about casual social interaction in a way that doesn't related to status.
(Whew, long post)