There's a lot of factors that ultimately determine how I would feel about the status update.
-Usually, a lot of statuses get pushed down from the "recent statuses" list due to high activity, so I can understand that since my status did not get enough publicity, that it obviously wouldn't get a response, unless people view my profile page and have a chance to do so. If that is the case, then,
-If my post is something random or not really relevant to MLP (talks about YouTube or something else), then I can't expect the audience to know much about the topic anyways. My most common status is a joke (which might not have enough curious viewers), so if enough time passes by, I'll just go "oh well", and post the punchline.
-If it's something serious or an issue I have that I posted, or if I ask someone to message me, I might just feel a bit disappointed and think that nopony out of the many who are online wishes to just chat with a fellow brony. But, I'm usually fine if I don't get a response, overall.