Of course I'd wish they were real, who wouldn't? If I could, I'd spend time just hanging out with the Mane Six, probably Twilight the most because she'd open up the most to me (at least, in my mind she would). Applejack would be awesome to chat with too, but Fluttershy would take the cake by far. I mean, she's freaking adorable and I share a lot in common with her (I'm also an introvert, love animals, etc.), but I know she'd probably be the least likely to converse with me, so it's a bit of a hopeless wish.
That said, as others have mentioned here, it would present a problem if they hung out here, so going there would be the safest for them. That said, though, if any of them came here and while we were together someone threatened us...(pulls out shotgun) they'd be sorry they messed with any of the ponies.
If they did come here, though, I'd be happy to show them the local attractions (from a safe distance, of course), and do really whatever they wanted to.