I think there should be an episode about some guy teleported by mistake in ponyville,everypony is having doubts about him,then the mane 6 will take care of him until Celestia sends him back to earth.It should take one episode so that there won't be much human stuff,also everypony's reaction would be nice to see, that guy telling them a little about earth,pretty much like the Zecora episode but harsher,emotional.(you will know if you read any human/pony crossovers in Equestria fanfics)
The again the show is "My little pony" so everything humanish,let alone the humans must be irrelevant.