Yes and no . It is a boardgame similar to an existing one named Arkham Horror, although it only borrows the mechanics and numbers from there, Ponyville Mystery is actually art-wise completely self-made. The game is about playing as a minor character or OC (if one likes to create his characters with the character sheet template), walking through Ponyville and solving investigations. Along with your character comes a set amount of money, set items, randomized items, skills and sometimes even a pet. Most rounds you stop at a location of your choice and get a card of said location, describing what is going on there. Mostly you need to pass a check (Combat-check, Speed-check, Lore-check, etc.) depicting the outcome of an event and the better your character is in that field, the more dice you can use trying to pass.
Every character has unique strengths and weaknesses, along with special abilities. Item, such as this box, help you with these tasks.
A little example:
Say you chose Nurse Redheart as your character (http://ponyvillemystery.deviantart.com/art/Nurse-Redheart-Investigator-Card-357458955). Every pairing of stats (Speed/Sneak, Fight/Will, Lore/Luck) is linked to each other. For example... the more lore you choose, the less luck you have (you indicate your choice by placing a marker there)
You now decide to go to the Poison Joke Field http://konsumo.deviantart.com/art/Gameboard-Poison-Joke-Field-494912017
(maybe to avoid an enemy you are not keen to fight or you are on your way to Zecoras Hut to learn about a magic spell).
You end your turn there and get a card, for example this one: http://konsumo.deviantart.com/art/Deep-Everfree-Forest-06-496797130
You now have to pass a Luck check (-1) in order to be lucky enough to notice an item. This means you look up how much Luck you currently have, subtract 1 (because it is a -1 check) and roll this amount of dice. If its a five or a six, you succeed, getting the item.
Some items grant a bonus to certains stats and can help you (for example http://konsumo.deviantart.com/art/Firefly-Lantern-376277358 )
I started off by creating the different shapes and parts from paths rather than just drawing it. After that I shaded it, worked on textures and only after that I added in all the little details. The inscriptions, ornaments and such are most of the work to be fully honest but I really like fiddling around with all the little details. I love the idea of exploring a picture, noticing details and sometimes even finding hidden messages the artist left.