Yeah, if I was human, I would be glad that Lyra isn't best pony. She would become OBSESSED about kissing a human (and maybe try to do other funny stuff).
If I was a pony though, and got kissed by my 4 favorite ponies, Rarity, Rainbow Dash, Dj Pon-3, and Derpy...
Well Rarity I would get to know her more before kissing her back, and I would probably try to start a relationship. She is best looking pony though.
Rainbow Dash I would be kinda wierded out because she is such a tom boy and probably wouldn't be interested in that stuff. http://mlpforums.com/public/style_emoticons/default/dry.png
Dj Pon-3 I would become extreamly head over heels for her, and I would probably enjoy it more because she isn't focused on partying with friends, but is a whole different person to me... I don't know, because she acts like the biggest crush I ever had IRL.
Derpy....... Let's not try to think about that.