These are quite random, and for now I can see that atleast two of them is utterly stupid. The pet one and the Spike x Twilight one, but I'll answer anyways.
1. If you saw Pinkie with a machine gun, what would you do?
Depening on her hairstyle (Poofy vs. Flat) I would probably only be worried if her hair was flat. If it was flat, I would of course try to calm her down and get her happy again, both because I would care about her well being as well as I would be a bit worried about what she might do with the machine gun, but then again, she have got hooves, she wouldn't be able to trigger it easily.
2. Which 2 ponies from the mane six do you want as pets?
This is a stupid quesion. They're living, thinking beings, as smart as you an me, Twilight probably even smarter. They don't deserve to be treated as pets but as equals. Which of the two I would want as a FRIEND is how I will answer this, since the question you gave is outright cruel.
I would like Twilight and Pinkie Pie as my friends. I would have a lot in common with Twilight, and I believe having Pinkie as a friend would be one of the nicest things in the world because of her will to make everypony happy.
3. What would you do if you saw Applejack crying out in the fields?
I would analyze the situation, if she seemed angry and upset, I would leave her alone until she calmed down, but if she was just there by herself, sulking in her own hooves then I would go put a hand under her cheek and wipe away the tears, asking what is wrong. I would then listen if she wanted to talk and I would offer any assistance she would require to become happy again.
4. What would you do if you came home to find Twilight asleep on your couch?
Well, I would probably wait for her to wake up and then ask what she is doing there and how she ended up in my couch in the first place. If it was a cold time of the day/year I would put a blanket over her since I wouldn't want her to catch a cold.
5. What would you do if you saw Fluttershy eating spaghetti?
It depends on the situation, I would greet her if it was on a restaurant as I passed by. If it was in any other situation it would probably be in her home or mine, meaning I would have a reason to be there in the first place. If that is the case, I would just enjoy the company of such a lovely mare.
6. What would you do if you saw Derpy trying to open a jar of peanut butter?
If she seemed to struggle with it, then I would offer my help, if not, I would probably not mind her.
7. Do you think Spike should have Twilight as his girlfriend instead of Rarity?
Another stupid question. Spike was raised by Twilight since she was a little filly, his role to her is a little brother. What you asked me now was if I think Twilight should be with his little brother? No... Spike would be better off finding someone on her own age, one of the CMC for example.
8. If you could bring two ponies to go bowling with you, who would they be?
Vinyl Scratch, and since my headcanon pairs up Vinyl with Octavia, then I bet she would come too.
9. Would you have a race with Rainbow Dash, or Applejack?
Since I'm a human, and I don't have wings, and also because of the fact that Rainbow is entitled as the fastest pony of Equestria, I would choose AJ.
10. What would you do if you saw Lyra on the road, about to get hit by a truck?
I would of course her if I could, if necessarry I would push her out of the way and take the hit myself.