Twilight's best friend.

[CastletonSnob 3,025]

Twilight, being the Princess of Friendship, has a lot of close friends. But who is her absolute BEST friend? 

[----- 476]

I say Spike, since they are together since he was born.

Plus he is her assistant and always there when she needs his help.

Edited January 29, 2017 by Fluidty

[Luminance 2,181]

Shining Armor her Big Brother Best Friend Forever.

[heavens-champion 1,893]

Why choose one best friend when they can all be her best friends.

[Tropico 225]

I say spike too. she trustes him when she has problems or doubts.

i mean the others too, but him first  :-P

[Singe 2,109]

I was thinking Applejack because Twilight hasn't nuzzled any other pony in the show.

[Colourful Blast 66]

Fluttershy. When the ponies begged for twi's ticket she didn't expect Flutters to do so.

[Mast. Equestos/Gigas 340]

I would go with Spike of course. He is an assistant and has been there with her longer before she met the gang. ^^

[cmarston1 5,952]

Given the events of Rainbow Rocks, Twilight and Sunset Shimmer have become really close together.

 

But if she doesn't count, than I would have to go with her number one assistant/ little brother/son combo, Spike.

[Zachary 5,517]

Twilight Sparkle Best Friend will be Spike!

[Victoria Sponge 1,014]

Spike of course, he's been with her all his life and almost all of hers and they live together. 

[Guest]

Why choose one best friend when they can all be her best friends.

 

That's what I thought as well - I don't really see it as a necessity to pick favorites. Even the theme song says that they're all best friends. 

[NeonCobalt 256]

Definitely Spike. He's basically known her his entire life and has stood by her no matter what.