I would think the mane six are less relate-able now. There are two extremes to this spectrum of relate-ability, and unfortunately I see those two all too often. On one end you have the "average high school life," which is completely devoid of interesting circumstance, and to the other you have the "invincible hero chosen by the gods" which only works for the narcissistic crowds who view themselves as such
I don't think mlp exists to either extreme currently, but I believe twilight ruling on her own was the preferable arrangement.